What is it?
Gonorrhoea is probably as old as civilisation itself, with references dating back to Chinese medical texts from 2600BC. In the 1940s, with the introduction of penicillin, gonorrhoea became little more than an inconvenience, a problem easily cleared with a single doctor’s visit.
Penicillin remained a reliable clap killer until 1976, when the mutating microbe finally gained the upper hand over that go-to antibiotic. Over the following decades, gonorrhoea quickly overpowered each new antibiotic that doctors threw at it. In 2007, the afflicted could rely on only one class of drugs, called cephalo-sporins.
By 2012, the US Centres for Disease Control and Prevention recommended switching from an oral form of cephalosporin to an injectable version that would pump higher concentrations into the patient’s bloodstream.
Today, we live in the era of the supergonorrhoea.
Drug-resistant gonococci are now spreading to such an extent that the World Health Organization has declared gonorrhoea a global concern, and warned that without new drugs, infections may one day become untreatable.
“This is clearly a superbug,” says Dr Peter Leone, an infectious disease specialist and professor of medicine at the University of North Carolina in the US. He predicts that gonorrhoea will eventually conquer the only remaining drugs it now succumbs to, as it has done with all the drugs thrown at it in the past half century.
And it’s not just a penis-vagina problem anymore. Now, more cases of gonorrhoea are in the throat or rectum, Dr Leone says. “In those sites, people often don’t have symptoms.”
This new development will allow gonorrhoea to move silently from person to person, with little to slow it down.
How bad is it?
Each year, gonorrhoea infects around 107 million people worldwide. The rate has remained relatively flat for about a decade.
What worries public health officials is the upward creep in drug resistance to cephalosporins, and how loss of the final treatment now on the market might redirect transmission.
Around 0.1 percent of infections tested in 2008 showed some resistance to ceftriaxone. That figure had quadrupled to 0.4 percent by 2011 but dropped back down after doctors started increasing the amount of drug given for treatment.
If those numbers sound tiny, realise that an antibiotic is usually dropped due to ineffectiveness when the proportion of resistant infections hits 5 percent.
Consider this: in 2014, doctors in Sweden writing in the journal Eurosurveillance described the challenges they faced trying to eliminate resistant gonorrhoea from the throats of four men and women. In three of them, 500mg of ceftriaxone hadn’t so much as budged the infection. Eradication eventually required 1,000mg of the antibiotic.
To combat resistance, US doctors now routinely administer injections of 250mg of ceftriaxone, along with a second antibiotic for seven days as back-up. That strategy appears to be working – for the time being.
In the past two years, the percentage of gonorrhoea cases with resistance to ceftriaxone has dipped. Still, no one thinks the problem is solved.
“We’re hitting gonorrhoea with a sledgehammer,” says Dr Jeffrey Klausner, a public health infectious disease specialist at UCLA, “but we’re running out of sledgehammers.”
Stopping the disease will ultimately require new drugs, but there hasn’t been any for more than a decade. Between 1930 and 1962, about 20 new classes of antimicrobial drugs came on the market. Since then, only two have debuted, the last one appearing in 2003.
That’s why a potential new antibiotic received an explosion of media attention this past January, even though it had been tested only in mice. The economics of drug development favour medicines that people take often and for a long time, like treatments for high cholesterol or arthritis. (Recent legislation has tried to encourage antibiotic development by making the finances more attractive.)
At the same time, unlike drugs for chronic diseases, antimicrobials carry the unfortunate distinction of losing effectiveness as years go by. Bacteria develop resistance through exposure to doses of antibiotics that don’t wipe out the entire colony. The aftermath leaves behind just the bugs that were able to outmanoeuvre treatment. Those resistant bacteria can then spread to other people.
Experts also warn that the widespread use of antibiotics in the food industry could foster the development of resistant organisms by exerting a constant, low-level survival pressure on bacteria. It’s as if we’re putting them in training and helping them build more strength.
Since 2012, in order to help preserve the power of cephalosporins, the US Food and Drug Administration has banned their use to promote growth of livestock.
How does it affect us?
Resistant gonorrhoea tends to arise in Asia, which is home to both a thriving sex tourism industry and readily available antibiotics.
The initial signs of serious trouble for ceftriaxone appeared in 2007, when Japanese physicians reported the cases of four infected men who’d had sex with prostitutes. Each of the men required a then-unheard-of 1,000mg of the drug to be cured.
In 2011, doctors described a gonorrhoea strain discovered in the throat of a 31-year-old sex worker in Kyoto who had come in for routine screening. Her infection also required 1,000mg.
Can’t get any worse than that… right?
Gonorrhoea is just one chapter in a larger story of global drug resistance. So many infections are now resistant to treatment that in 2014 an official with the World Health Organization warned that “without urgent, coordinated action by many stakeholders, the world is headed for a post-antibiotic era, in which common infections and minor injuries which have been treatable for decades can once again kill.”
A lot of microbes resist drugs that attack them, but gonococci are notoriously skilled at it.
For instance, a single gonococcal microbe can scavenge genes from its neighbours, splicing the new DNA into its own genome. If another organism, even one of a different species, carries genetic code for a molecule that disables a drug, it can share it with gonococci that were never even exposed to the medicine.
Should gonorrhoea pick up the means for cephalosporin resistance from another kind of bacteria, it wouldn’t be the first time. In the 1980s, gonorrhoea became resistant to the antibiotic tetracycline by stealing genes from group B strep, a bacterium that causes a sore throat.
Even worse is the fact that gonococci will huddle among the bacterial masses at the back of the throat, giving the organism an entire lending library of helpful genes to choose from. “It is the ultimate social network,” says Jonathan Zenilman, M.D., chief of infectious diseases at Johns Hopkins Bayview Medical Center in the US.
And because 90 percent of people who have gonorrhoea in the throat are completely unaware that they are infected, they have no reason to seek treatment.
Of the four Swedish patients with highly resistant gono-cocci, only one had a scratchy throat. The other infections were discovered with routine samples. How do you treat a disease no one feels? How do you stop its spread?
Is there still hope?
It’s easy to dodge a superbug: Pass a gonorrhoea screening, and have a monogamous relationship with someone who is bug-free. Failing that…
1. Get screened, share results
If you’re having casual sex with multiple partners, get tested to find out for sure whether you’re infected with any sexually transmitted disease.
2. Use a condom (part 1)
Some common errors: Putting the condom on only after intercourse has already started; realising that it’s on inside out and flipping it over slightly used; opening the package with something sharp (fellas – no teeth!); and using an oil-based lubricant, such as petroleum jelly.
3. Pass the oral exam
The back of the throat can also harbour gonorrhea – and 90 percent of the time, the infected person has no symptoms. However, you can’t get it from normal kissing. Infection requires the tip of your penis to come into direct contact with the bacteria.
4. Use a condom (part 2)
Yes, you do need protection – even during oral sex. Think that’s no fun? Try gonorrhoea.
5. Educate yourself
For the very latest info about infection rates, preventive strategies, and other tips that can save your sex life, check with the Singapore Health Promotion Board.
By: Laura Beil